Senior / Principal Scientist: In Vivo Biology

About Us:

Founded in 2017 by scientists from Harvard and UCSF, Autonomous Therapeutics is developing new classes of target-activated RNA medicines from influenza to cancers.

The first-in-class antiviral and anticancer therapeutics in our pipeline are designed to be both precision-activated and variant-proof. For example, we are working to develop pan-influenza prophylactics and chemotherapies that (autonomously) detect cancer cells and avoid healthy cells.

We're looking for an exceptional in vivo biologist to join our growing team of in our 18,000 square foot R&D facility in Rockville, Maryland.

About You:

We are looking for a rigorous and hands-on in vivo biologist who wants to develop and test next-generation medicines from cancers to respiratory viral pathogens.

This position focuses on in vivo biology, but you will also have the opportunity to hone new skills (from RNA engineering to robotics)—and contribute across our therapeutic pipeline.

You would join a growing team of PhD scientists and report directly to the President of R&D.

Job Type: Full-Time

Qualifications:

  • This position requires a Ph.D. and at least 4 years of hands-on expertise in:

    • Model Development in vivo: Developing viral or oncology models in mice (e.g. respiratory viral infection models, tumor models, models in immunodeficient mice).

    • Therapeutic or Vaccine Studies in vivo: Testing and probing countermeasure candidates in mouse models for any indication, including: viruses, solid tumor cancers, or autoimmune diseases.

    • Immunology in vivo: Expertise isolating immune and other cells from mice (e.g. from blood, lungs, liver, lymph nodes, and spleen) as well as expertise in analyses, including: RT-qPCR, in vivo imaging (IVIS), and flow cytometry.

Preferred Qualifications:

  • Additional expertise in at least of the following areas is highly preferred:

    • Virology: Expertise developing and testing antivirals: e.g. for respiratory viral indications (e.g. via inhaled delivery) or in immunodeficient models.

    • Cancer Biology: Expertise probing novel cancer medicines or detection modalities, including: monoclonal antibodies, immunotherapies, or cell therapies (e.g. CAR-T).

    • Nucleic Acid Biology: Expertise with mRNA, siRNA, oligonucleotide, or gene therapies, or with novel methods of nucleic acid delivery (e.g. LNP, conjugation).

Critically, your specific area of expertise is less important to us than your passion for discovery!